15
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T22980 | MIRA-1 | p53 Activator VIII,1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione,(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate,NSC 19630,WRN Helicase Inhibitor | DNA/RNA Synthesis , p53 |
MIRA-1 (WRN Helicase Inhibitor) is a restorer of wild-type p53 conformation/cellular function and selectively inhibits Werner syndrome WRN helicase activity with an IC50 of 20 µM. | |||
T9168 | NSC 617145 | NSC617145,NSC-617145 | DNA/RNA Synthesis |
NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner. | |||
T5413 | ML216 | CID-49852229 | DNA/RNA Synthesis |
ML216 (CID-49852229) is a small molecule inhibitor of BLM helicase (IC50: 1.8 μM). It showed 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s > 50 μM). | |||
T40823 | NCGC00029283 | DNA/RNA Synthesis | |
NCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), displaying inhibitory activity against WRN helicase with an IC 50 value of 2.3 μM. Additionally, it exhibits inhibitory effects on Bloom synd... | |||
T72107 | Werner syndrome RecQ helicase-IN-1 | DNA/RNA Synthesis | |
Werner syndrome RecQ helicase-IN-1 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer. | |||
T68815 | NCGC00063279 | ||
NCGC00063279 is a novel inhibitor of the werner syndrome helicase-nuclease (wrn) helicase | |||
T79178 | WRN inhibitor 2 | DNA/RNA Synthesis | |
WRN Inhibitor 2 (example 118), a potent inhibitor of the WRN (Werner Syndrome ATP-dependent helicase enzyme), exhibits a pIC50 value of 7.0 or greater [1]. | |||
T72110 | Werner syndrome RecQ helicase-IN-4 | ||
Werner syndrome RecQ helicase-IN-4 is a potent, orally active inhibitor of Werner syndrome RecQ helicase (WRN) with an IC50 of 0.06 µM, exhibiting both antiproliferative and anticancer activities. | |||
T72109 | Werner syndrome RecQ helicase-IN-3 | ||
Werner syndrome RecQ helicase-IN-3, a potent and orally active inhibitor of Werner syndrome RecQ helicase (WRN), exhibits anticancer and antiproliferative activities with an IC50 value of 0.06 µM. | |||
T79107 | WRN inhibitor 1 | DNA/RNA Synthesis | |
WRN Inhibitor 1 (example 7) is an inhibitor of the Werner Syndrome ATP-dependent helicase enzyme (WRN), selectively targeting its helicase domain. This compound is potentially useful for cancer research [1]. | |||
T78938 | H3B-968 | DNA/RNA Synthesis | |
H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) with an IC50 of approximately 10 nM, effectively targeting its helicase, ATPase, and exonuclease activities. While WRN is known for its synthetic lethal acti... | |||
T72108 | Werner syndrome RecQ helicase-IN-2 | ||
Werner syndrome RecQ helicase-IN-2 (example 57), a potent inhibitor of the Werner syndrome RecQ DNA helicase enzyme (WRN), holds potential for use in cancer research. | |||
T80773 | WRN inhibitor 4 | ||
WRN Inhibitor 4 (Example 107), a cyclic vinyl sulfone-based compound, serves as an inhibitor of the Werner Syndrome ATP-dependent helicase enzyme (WRN). This inhibitor is applicable in cancer research [1]. | |||
T80772 | WRN inhibitor 5 | ||
WRN Inhibitor 5 (Example 157), a cyclic vinyl sulfone-based compound, serves as an inhibitor of Werner Syndrome ATP-dependent helicase enzyme (WRN). It is utilized in cancer research [1]. | |||
T80774 | WRN inhibitor 3 | ||
WRN Inhibitor 3 (example 110), a cyclic vinyl sulfone-based compound, serves as an inhibitor of the Werner Syndrome ATP-dependent helicase enzyme (WRN). It is utilized in cancer research [1]. |